In the procurement of cosmetics and chemicals, products of different specifications possess distinct functionalities. As a raw material component with diverse applications across multiple fields, methylene blue trihydrate (CAS 7220-79-3) raw powder comes in various specifications. When procuring this material, attention must be paid not only to "safety" but also to ensuring that "the purity grade of methylene blue trihydrate meets the requirements of the intended application."
Methylene Blue Trihydrate bulk powder is a deep green crystalline powder in its hydrated form, CAS: 7220-79-3. It can be used as a redox agent, dye, and more, and is commonly applied as a cosmetic ingredient powder in the cosmetics industry. Its chemical formula is C₁₆H₂₀ClN₃OS. Unlike the anhydrous form (CAS 61-73-4) of the raw material powder, it exhibits significant differences in application and specifications.
Pharmaceutical Grade vs. Industrial Grade
The safety of methylene blue trihydrate depends on its impurity profile. Below are the differences between the two grades available in wholesale markets
| Feature | USP / Pharmaceutical Grade | Industrial / Technical Grade |
| Assay Purity | 98.0% – 103.0% (Dry Basis) | Often < 90% or Unspecified |
| Heavy Metals | Strictly Limited (e.g., Arsenic < 8ppm, Lead < 2ppm) | High risk of Mercury, Lead, and Arsenic |
| Organic Impurities | Controlled (Azure A, B, C, and Thionin) | Contains reaction by-products |
| Intended Use | Medicine, Clinical Research, Diagnostics | Textiles, Plastics, Aquarium cleaning |
| Documentation | Full COA, MSDS, Compliance | Basic Technical Data Sheet |
Methylene Blue trihydrate Chemical Properties |
| Melting point | 190 °C (dec.)(lit.) |
| bulk density | 400-600kg/m3 |
| density | 0.98 g/mL at 25 °C |
| Fp | 14 °C |
| storage temp. | no restrictions. |
| Colour Index | 52015 |
| form | Solid |
| pka | 2.6, 11.2(at 25ºC) |
| color | Green |
| PH | 3 (20°C, 10g/L in H2O) |
| Water Solubility | 4 g/100 mL |
| λmax | 668 nm, 609 nm |
| Stability: | Stable. Incompatible with bases, reducing agents, strong oxidizing agents. |
| InChIKey | YAFGUSOAMIMROI-UHFFFAOYSA-M |
| CAS DataBase Reference | 7220-79-3(CAS DataBase Reference) |
| IARC | 3 (Vol. 108) 2016 |
| EPA Substance Registry System | Methylene blue trihydrate (7220-79-3) |
Is methylene blue trihydrate safe?
Yes, provided it meets United States Pharmacopeia (USP) standards or your procurement specifications. When sourcing products for B2B applications, you may review the qualifications of methylene blue trihydrate raw powder manufacturers and various testing documents.
Jinan SinoBio Technology Co., Ltd. specializes in supplying high-purity methylene blue trihydrate (USP grade), offering comprehensive documentation support and global shipping services.
Methylene Blue Trihydrate Certificate of Analysis (COA)
| Testing Items | Specifications | Results |
|---|---|---|
| Appearance | Dark green to dark brown solid powder | Conforms |
| Identification | ¹H NMR confirms to structure | Conforms |
| Loss on drying | ≤18.0% | 14.31% |
| Residue on ignition | ≤1.2% | 0.28% |
| Pb | ≤3.0ppm | <0.05ppm |
| As | ≤5ppm | 0.0151ppm |
| Cd | ≤1.0ppm | 0.532ppm |
| Hg | ≤0.1ppm | 0.0159ppm |
| Assay | ≥98.5% (on the anhydrous basis) | 99.47% |
Conclusion: This product conforms to the specifications.
Storage: Store in a well-closed and dry place with room temperature and no direct sun light.
Methylene Blue Trihydrate raw powder factory
As a supplier and manufacturer of high-purity Methylene Blue Trihydrate, Jinan Sinov Biotechnology produces high-quality Methylene Blue Trihydrate powder. The powder exhibits a deep green color, which may vary slightly between batches and depending on dryness. The powder exhibits good flowability with minimal crystallization and a fine particle size. It is packaged in a sealed plastic inner container and an outer aluminum foil bag. Typically, a 1kg sample of Methylene Blue Trihydrate powder is provided to customers. However, if you require 100g or 10g samples, customized packaging is available. For storage, protect the product from moisture and light exposure to maintain its stability.
Disclaimer:
The information on this website is for communication and learning purposes only and is not medical advice. It should not be used for diagnosing or treating any illness.
