What Is Coptis Chinensis Extract?
What exactly is Coptis Chinensis Extract Powder? The primary active ingredient in Coptis Chinensis Extract is berberine. Extracted from the roots of Coptis chinensis, berberine is processed into products like berberine powder. It functions as an anti-inflammatory agent with significant medicinal value.
Jinan Sinov Biotechnology Co., Ltd. produces and sells high-quality food-grade Coptis Chinensis Extract Powder (Berberine), widely used by health supplement companies in dietary supplements. It may offer potential benefits for elderly hypertension. Research indicates that berberine may be effective in improving arrhythmia and heart failure.
Production Process
1. Preparation of Piperethamine
Lignocresol undergoes isomerization under reduced pressure to form isolignocresol, which is then oxidized to produce piperonal. Piperonal reacts with nitromethane to form β-nitro-3,4-dioxymethylstyrene, which is further reduced to yield piperethamine.
2. Condensation and Hydrogenation of Piperethamine
Peperonyl ethylamine undergoes condensation with o-cinnamaldehyde in anhydrous ethanol to form an intermediate. This intermediate is then subjected to catalytic hydrogenation in an autoclave using a nickel catalyst and hydrogen gas at 4 MPa and 80–90°C, yielding N-2,3-dimethoxybenzyl peperonyl ethylamine hydrochloride with a yield of approximately 84%.
3. Cyclization and Preparation of Crude Berberine
The above hydrochloride salt reacts with a system containing glacial acetic acid, acetic anhydride, copper sulfate, and sodium chloride. Ethylene glycol is then added to promote intramolecular cyclization, yielding crude berberine trichlorohydrate.
4. Purification of Berberine and Production of Berberine Hydrochloride
The crude berberine undergoes liming, acidification, and decolorization to yield pure berberine hydrochloride, the form commonly used in pharmaceuticals and industry.
5. Comparison of Plant Extraction Methods
Beyond chemical synthesis, berberine is widely present in plants like Berberidaceae. The traditional extraction method involves slicing, sun-drying, and grinding plant rhizomes, followed by multiple soakings in 0.5% sulfuric acid solution. Berberine is then obtained through salt precipitation and acid-base purification. Typically, 100 kg of crude drug yields approximately 0.5 kg of finished product.
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