Bulk Kavakavaresin Powder

Kava has a primary root 1cm in diameter, 5-8 branching lateral roots, dark brown, hairy roots, and a root body greater than 8cm in length, with a pungent odor and a slightly sour taste. Perennial shrubs, up to 6m high; erect, 3cm to 8cm in diameter, up to 20cm; leaves are stalked heart-shaped, sharp-angled, entire, green and smooth on both sides, about 15cm long; fleshy spikes, yellow-green florets; the root has a pungent, bitter flavor.

Kava pepper is a perennial shrub of the Piperaceae family, and in some parts of Africa, the root of Kava pepper and the wine made from it are collectively known as "Kafa" (Kava, Kawax).

The United Kingdom will be included in the "Botanical Pharmacopoeia", the United States included in the new version of the "U.S. Pharmacopoeia", many countries in Europe and the United States will be listed in the Kava as over-the-counter drugs or prescription drugs.

Kava is a tropical/subtropical low-growing shrub, mainly distributed in the South Pacific Islands, with 30% of the core active ingredient kavalactones in its extract.

Classification of the main chemical components

1.Lactones
α-Pyranone derivative system:
- Narcotic pepper bitterin (Methysticin) and its derivatives (dihydro/5,6-dehydro/11-methoxy modifier)
- Drunken peppercorn complex (methoxy-drunken peppercorn/goat koinin and its demethoxylated variants)
- Dimer type: sheep gonin dimer, demethoxy sheep gonin dimer

2.Alkaloids
Pyrrolizidine alkaloids: leaf enriched with narcotic pepperine (proposed), present in small amounts in roots (structurally unstable)

3.Amides
Various trace amide components

4.Organic acids
18 organic acids such as kavalic acid and piperic acid, with special 4-oxo-n-nonananoic acid

5.Special ingredients
Pigment component: Flavokavain A/B/C
Fluorescent substance: Orange high fluorescent Capharadion A
Polymer: N-vinylpyrrolidone, etc.

• Sleeping aid effect of kavalactones

Mechanism of action: kavalactones act directly on the central nervous system of the brain limbic system, regulating the balance of the human central nervous system, eliminating harmful substances formed in the brain due to environmental malignant stimuli.

Relieve bad mood: Effectively resolve tension, anxiety and other adverse reactions, helping to stabilize the mood, which is conducive to sleep.

Improve sleep quality: Taking Kavalactones-containing Kava Root can improve the quality of sleep, create a natural sleep state, and help cure insomnia.

Overall Evaluation: Kavalactones have a significant sleep-aiding effect, mainly by regulating the central nervous system balance and relieving bad moods to improve the quality of sleep.

• Anxiolytic Effects of Kavalactones

Kavalactone is a natural medicinal ingredient extracted from the root of the kava plant. It has sedative and relaxing effects and is widely used to regulate mood and relieve anxiety.

Mechanism of action: Kavalactones produce sedative and anxiolytic effects by binding to GABA receptors in the brain and increasing GABA activity. This mechanism allows kavalactones to provide a relaxing effect without affecting cognitive function13.

Clinical Trial Verification: Several studies have shown that kavalactones can relax symptoms in patients with anxiety disorders.

• Soothing effect on the skin

Kava pepper extract can effectively relieve skin tightness and discomfort, skin problems caused by the change of season, air-conditioned environment, irritating cosmetics, and sensitive skin after contact with allergens allergy symptoms are improved, can help the skin to restore the state of comfort, reduce itching, tingling and so on.

Its mechanism of action is:
①Neuromodulatory effect of the key active ingredient kavalactones can interact with specific receptors such as TRPV1 on the skin nerve endings. When the skin is stimulated TRPV1 channel activation will lead to cation in-flow to generate nerve impulses, and the extract can inhibit the activation of TRPV1 channel, reduce cation in-flow, from the nerve signaling "source" control, reduce skin sensitivity, relieve tightness, tingling and other discomforts.
② cell signaling regulation in the skin cells, the extract can regulate such as cAMP and other intracellular signaling pathways. When the skin is stimulated by intracellular cAMP levels will normally rise to trigger skin sensitivity, this extract can inhibit the excessive increase in cAMP, so that the cells to maintain a stable state, reduce skin stress.

 Note: TRPV1: skin sensory-related protein, activation of which causes pain, itching and skin sensitivity. cAMP: cyclic adenosine, the second intracellular messenger, involved in the regulation of cellular physiological functions, the level of which is closely related to the state of skin stress and sensitivity.

• Antioxidant effects

Kava pepper extract achieves its anti-aging benefits through a dual mechanism:

Free radical scavenging mechanism
The active ingredient contains phenolic hydroxyl groups (-OH directly linked to the benzene ring), which act as hydrogen donors to react with free radicals, terminating oxidative chain damage to lipids/proteins/DNA and protecting skin cell integrity.
Endogenous antioxidant activation
Activate Nrf2-ARE pathway: stimulate nuclear transcription factor Nrf2 into the nucleus, combined with antioxidant response element (ARE), up-regulate SOD, GSH-Px and other enzyme genes expression, strengthen the cell's ability to independently scavenge free radicals.

①With Chamomile Extract
Kavalactones and Chamomile active ingredients form a dual anti-inflammatory barrier that reduces the activity of inflammatory factors and strengthens the lipid structure of the stratum corneum. The combination synergistically reduces skin inflammation and soothes the skin, and also strengthens the skin barrier function. Suitable for sensitive and allergy-prone skin, relieving allergies and redness.

②Pairing with Ceramide
Ceramide builds a "brick wall structure" in the epidermis, while kava extracts inhibit inflammatory signaling at the deepest level, forming a three-dimensional repair system of "external protection + internal stabilization". Suitable for barrier damaged and sensitive skin.

③With Vitamin C
Vitamin C neutralizes free radicals, brightens skin tone and promotes collagen synthesis. Combined with Kava pepper extract, it enhances the antioxidant effect, protects against oxidative damage, improves skin condition, and effectively improves the dullness of skin tone caused by photoaging.

④With Hyaluronic Acid
Hyaluronic acid forms a three-dimensional moisturizing network in the stratum corneum, which has the effect of moisturizing and locking water, while kava extract regulates the skin's micro-inflammatory state and reduces transdermal water loss (TEWL). Suitable for dry and sensitive skin.

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