Ademetionine disulfate tosylate(SAME), also known as S-Adenosyl L-Methionine Disulfate Tosylate,SAMe is a small molecule that is involved in more than 200 biochemical reactions in the human body.
Development History of Ademetionine Disulfate Tosylate
1970s
Europe begins using SAMe as a prescription drug for treating arthritis.
Mid-1980s
SAMe is first recommended in Europe as an antidepressant and psychotropic drug.
1990
SAMe passes randomized, double-blind clinical trials approved by the FDA in the United States.
1996
The FDA officially approves enteric-coated and oral SAMe as an over-the-counter (OTC) drug in the U.S., expanding its clinical applications.
1999
The FDA approves SAMe as a dietary supplement in the U.S., making it one of the fastest-growing supplements. U.S. annual sales exceed $100 million.
Preparation of Ademetionine Disulfate Tosylate
The preparation of Ademetionine Disulfate Tosylate can be divided into chemical synthesis, extraction by microbial fermentation or in vitro enzymatic synthesis.
Yeast fermentation or chemical synthesis is the traditional production method of SAME, but there are generally problems such as low conversion rate, inactive isomers that are difficult to separate in the product, and long production cycle (about 7 days). The cost of the terminal product due to the complex purification process is one of the key factors restricting the industrial development of SAMe.
Chemical synthesis can significantly improve production efficiency and reduce costs.
COA
| Test Items | Specifications | Results | |
| Appearance | White to off-white Powder | White to off-white Powder | |
Identification |
Infrared | Conforms to the Reference Spectrum | Complied |
| HPLC | The retention time of the major peak corresponds to the reference sample |
Complied | |
| Water Content(K.F) | 3.0% MAX | 1.1% | |
| Sulphated Ash | 0.5% MAX. | Complied | |
| PH (5% AQUEOUS SOLUTION) | 1.0 -2.0 | 1.3 | |
| S, S-Isomer (HPLC) | 75.0% MIN | 83.8% | |
| SAM-e ION (HPLC) | 49.5 - 54.7% | 52.1% | |
| P-Toluenesulfonic Acid | 21.0%-24.0% | 22.2% | |
| Content of Sulfate (SO4) (HPLC) | 23.5%-26.5% | 25.0% | |
| S-Adenosyl-L-methionine Disulfate Tosylate | 95.0%-103% | 99.3% | |
| Related substances(HPLC): | |||
| - S-ADENOSYL-L-HOMOCYSTEINE | 1.0% MAX. | 0.1% | |
| - ADENINE | 1.0% MAX. | 0.1% | |
| - METHYLTHIOADENOSINE | 1.5% MAX | 0.2% | |
| - ADENOSINE | 1.0% MAX. | 0.1% | |
| - TOTAL IMPURITIES | 3.5% MAX. | 0.7% | |
| Heavy Metals | Not more than 10 ppm | Complied | |
| LEAD | Not more than 3 ppm | Complied | |
| CADMIUM | Not more than 1 ppm | Complied | |
| MERCURY | Not more than 0.1 ppm | Complied | |
| ARSENIC | Not more than 2 ppm | Complied | |
| Microbiology | Total Aerobic Count | ≤1000cfu/g | Complies |
| Yeast and mold count | ≤100cfu/g | Complies | |
| E. coli | Absent/10g | Complies | |
| S. aureus | Absent/10g | Complies | |
| Salmonella | Absent/10g | Complies | |
| Conclusion | Complies with USP37 | ||
Hot Product
|
Product Name |
CAS Number |
|
Ademetionine Disulfate Tosylate |
97540-22-2 |
|
S-Adenosyl-L-methionine |
29908-03-0 |
|
S-Adenosyl-L-Methionine Butanedisulfonate |
101020 -79-5 |
|
Lions Mane Extract |
N/A |
|
Mushroom extract |
N/A |
Where To Buy?
Jinan Sinov bio is Ademetionine Disulfate Tosylate factory,supply high purity Ademetionine Disulfate Tosylate(SAME),provide test reports and various certificates, provide customization of similar products and various cosmetic raw materials (OEM ODM)
OEM ODM Service
For cosmetic ingredients, plant extracts, and supplement ingredients, the company has extensive OEM ODM experience and can customize labels, packaging, and other content.
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How To Contact Us
1.Send the purchasing products, specifications, quantity, address and other information to us by e-mail.
2.The product manager will contact you at the first time.
3.After all negotiations, sign the purchase contract.
4.Delivery after payment for stock, and start production after payment for large special products.
Disclaimer:
All information provided on this website is for reference and study only, no medical advice, not for diagnosis, treatment of disease.
References:
[1] Wan Honggui, Guo Yidan, Cai Heng, Zheng Weigang. Research progress and market application analysis of S-adenosylmethionine [J]. Progress in Modern Biomedicine, 2008(10):1951-1955.
[2] Shen Li, Li Dongyang, Jiang Yongming, Yuan Zhongyi. Stability of S-adenosylmethionine and its stable salts [J]. Pharmaceutical Biotechnology, 2003(02):125-128. DOI:10.19526/j. cnki.1005-8915.2003.02.016.
[3] Yu Zhiliang, Yang Sheng, Cai Jin, Yuan Zhongyi. Research progress of S-adenosylmethionine[J]. Chinese Journal of Pharmaceutical Industry, 2003(01):51-54.
[4] Wang Hongmei, Zhao Xinqing. Current status and prospects of S-adenosylmethionine in the treatment of mental and nervous system diseases[J]. Foreign Medicine (Geriatrics), 2007(02):91-94.
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