What is Kojic Acid Dipalmitate?
Kojic Acid Dipalmitate is an ester derivative of kojic acid, exhibiting greater stability than the original compound. It appears as a white crystalline powder with a melting point ranging from 94.0 to 97.0°C. Insoluble in water, it readily dissolves in polar oils. This highly effective whitening additive demonstrates efficacy in skin whitening and sun protection.
Kojic Acid Dipalmitate Benefits
1. Tyrosinase is the primary enzyme responsible for melanin production. Kojic acid dipalmitate (KAD) inhibits tyrosinase activity, thereby treating hyperpigmentation and brightening the skin. A study prepared various KAD-loaded emulsion suspensions, ultimately finding that stable KAD carrier formulations enable deeper penetration into the skin, demonstrating potential efficacy for skin brightening and moisturization.
2. Kojic Acid Dipalmitate may inhibit UV exposure. One study found that hand creams containing α-arbutin, KAD, and hexylresorcinol improved both hyperpigmentation and hand wrinkles.
3. May address the following skin concerns: melasma, age spots, hyperpigmentation.
Applications
1. Kojic Acid Dipalmitate is compatible with a wide range of preservatives and sunscreen ingredients, making it suitable for inclusion in skin-lightening skincare products.
2. KAD may be incorporated into certain spot-removing agents to address hyperpigmentation.
3. This active ingredient may also be added to skin-lightening serums, brightening creams, and skin-conditioning treatments.
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Specification
| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
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Contact us get the best price: sinov@pharmachemm.com
Contact us get the best price: sinov@pharmachemm.com
Disclaimer:
The information on this website is for communication and learning purposes only and is not medical advice. It should not be used for diagnosing or treating any illness.
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